Description
Product Characteristics:
JIP-4 is a 1,321 amino acid protein encoded by the human gene SPAG9. It contains a large N-terminal extracellular domain, a short transmembrane helical domain, and a cytoplasmic domain. There are 6 N-glycosylation sites, several phosphorylation sites for cAMP/cGMP-dependent protein kinase, protein kinase C, and casein kinase II, and 10 putative myristoylation sites. There is also a leucine zipper motif, with 6 leucine repeats, that may aid in dimerization since there is no upstream basic domain characteristic of DNA binding proteins. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP-4 is a cytoplasmic, perinuclear protein that has eight known isoforms whose expression varies by tissue and disease state.
Subcellular location: Cytoplasm
Synonyms: C jun amino terminal kinase interacting protein 4, c Jun NH2 terminal kinase associated leucine zipper protein, FLJ13450, FLJ14006, FLJ34602, HLC 4, HLC 4 protein, HLC 6, HLC4, HLC4 protein, HLC6, HSS, Human lung cancer protein 6, Human lung cancer protein 6, JIP 4, JIP 4, JIP4, JNK associated leucine zipper protein 1, JNK associated leucine zipper protein, JNK interacting protein 4, JNK interacting protein 4, JNK interacting protein, JNK/SAPK associated protein, KIAA0516, Lung cancer oncogene 4, MAPK8IP4, Max binding protein, MGC117291, MGC14967, MGC74461, Mitogen activated protein kinase 8 interacting protein 4, Mitogen activated protein kinase 8 interacting protein 4, PHET, PIG 6, PIG6, proliferation inducing gene 6, Protein highly expressed in testis, SPAG 9, SPAG9, Sperm associated antigen 9, Sperm specic protein, Sperm surface protein, Sunday driver drosophila homolog, Sunday driver 1, SYD1, JIP4_HUMAN.
Target Information: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]